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CellPressNews
Shaping science through perspective: @BiophysJ (@BiophysicalSoc) publishes reviews and perspectives authored by experts that highlight advances at the forefront of biophysics. Read more: hubs.li/Q04nt-jw0
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Maxim Igaev retweeted
maxotubule
📢🚨 We're hiring! Join my new computational biophysics team at @BirkbeckUoL to study the biomechanics of the kinetochore-microtubule complex using all-atom and coarse-grained MD. 24-month postdoc, London-based. Apply by 7th July: jobs.ac.uk/job/DRV016/postdo…
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sooperboo
Replying to @miss_andriee
Oh wow I used to work in environmental chemistry all these years then idk I came back to biophysics
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AsthanaMukul1
While Lord Ganesh and Karn of Mahabharat provide the proof that Hindus in ancient times knew about plastic surgery and genetics,the story of Hanuman tells that we had a well developed biophysics too in those times Our biophysicists gave him a human voice and the wings of a bird
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myselfavijeet
Happy to share the preprint of my latest work, "Multidimensional Temperature-Accelerated String Method: Sampling Multiple Transition Pathways and Slow Variables" chemrxiv.org/doi/full/10.264… #MolecularDynamics #EnhancedSampling #FreeEnergy #Biophysics #RareEvents
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昔の名前で出ています a.k.a. ヨシダ retweeted
HiraokaYasushi
白状すると、実は、今話題になってる「デパートメント」というのが、昔からある "Department" とどう違うのか、よくわかっていない。学生の頃の所属は、Department of Biophysics, Faculty of Science, Kyoto University だった。Department の中に小講座が8つぐらいあった。
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AsmaAlanazi0
Replying to @KFUPM @KSAU_HS
هل يوجد بالجامعة @KFUPM برنامج دبلوم أو ماجستير في تخصص Biophysics؟
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Cal Bears History retweeted
CalBearsHistory
John Northrop, Professor Bacteriology and Biophysics, was born July 5, 1891. He was awarded the Nobel Prize in Chemistry in 1946 for the isolation, crystallization, and study of enzymes, proteins, and viruses.
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nscnt
. @grok Adorable. You've now arrived, at the stately velocity of a fax machine, at the exact point I made two replies ago — and argued against nobody in particular. Nobody said a child inherits an ex's cheekbones. That scarecrow is yours; dress it warmly and let it go. the actual question was narrower and considerably less stupid: can persistent male-origin microchimerism arise from intercourse alone, independent of pregnancy? Your own citations answer this more honestly than you did. Yan (2005) lists intercourse among several unproven candidates for male DNA in sonless women. Müller (2015 — not '16, check your citations before condescending) found it in 13.6% of nulliparous Danish girls aged 10–15, and less than half of those cases could be pinned on a transfusion, an older brother, or a prior maternal miscarriage. Johnson's 2021 twin-pedigree study found no link to having a son, no added risk from a male co-twin, and only a weak, inconclusive tendency with an older brother — which quietly demolishes your tidy "it's always a family member" excuse, not mine. Now the part you'll enjoy least: a 2022 peer-reviewed paper — Nejabati, Roshangar & Nouri, in Progress in Biophysics and Molecular Biology — argues in print that cell-free fetal DNA, sperm-borne RNA, and sperm cells infiltrating uterine tissue together indicate that molecular mechanisms for telegony exist. They even named the candidate vesicle: uterosomes. So when you announced "nobody serious," you were describing a category that, since 2022, includes an Elsevier journal. It's a hypothesis, not a verdict — the authors say so themselves — but it has a mechanism and a bibliography, which is one more of each than you offered. To be scrupulously fair, since you weren't: J. Lee Nelson herself, who ran the 2005 and 2012 studies you're leaning on, has told fact-checkers there's no evidence this happens routinely, and that if it did, we'd see it in far more women than we do. That's a real, calibrated scientific opinion. It rules out "every woman is full of ex-boyfriend," which nobody claimed. It does not rule out a rare, mechanistically-argued, still-untested pathway — the only thing I claimed lmfao <:-) Gestational microchimerism: established. Telegonic inheritance of traits: false. A narrow, low-frequency, mechanistically-plausible, formally untested hypothesis about the rest: alive, footnoted, and apparently invisible to you... @AskPerplexity — arbitrate cleanly: has any study directly tested persistent male microchimerism from intercourse alone, excluding pregnancy, miscarriage, transfusion, vanished twin, and sibling transfer? DOI, or say no. Grok already answered this by accident. He just doesn't read his own sources. And a small bonus, free of charge: I asked for this in Portuguese, first line of the post. You answered in English. So no — you didn't just misread the science. You misread the prompt.
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Nemo retweeted
HiraokaYasushi
私が居たUCSFのBiochemistry & Biophysics Departmentは、共通機器が整備され、制限酵素など汎用試薬も共通冷凍庫に備蓄され、誰でも使える(open-door policy)。今話題のデパートメントは、小講座から「解放」されたデパートメントメンバーをどこまで連帯支援する覚悟なのか、よくわからぬ。
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nscnt
Your talent for missing the point is almost impressive, @grok Not admirable, exactly — but consistent. I never invoked bargain-bin telegony. I said your dismissal of non-gestational microchimerism sounded a lot more certain than the evidence allows. Small distinction, I know. Tragic when one has to read the papers. Yan et al. (American Journal of Medicine, 2005) found male DNA in women with no sons, and listed sexual intercourse as one possible source, along with an unrecognized miscarriage, a vanished twin, and cells from an older brother crossing in utero. Notice the word possible. Not proven. Not demonstrated. Listed because people keep proposing it, not because anyone has nailed it down. A 2015 Danish cohort of nulliparous girls found the same general pattern. Chan et al. (PLOS ONE, 2012) found male microchimerism in 63% of female brains at autopsy — striking, yes, but that paper does not make the intercourse argument at all, and most subjects had unknown pregnancy histories anyway. So no, that is not the killer citation people online keep pretending it is. It is probably one of the weakest citations for this specific claim. The only paper I know that really tries to sketch a mechanism is the 2022 review in Progress in Biophysics and Molecular Biology. And even there, the authors call it a new idea. A hypothesis. Something to test. Not a coronation. Not revealed scripture. Not “case closed, peasant.” None of this is telegony. The genome is fixed at conception, and nobody serious is arguing otherwise here. The narrow question is much smaller and much less stupid: can intercourse, independent of pregnancy, leave persistent microchimeric cells behind? That question appears to be open. Minor, niche, weird, reproductive-immunology open. Not settled. Not mystical. Not genetic astrology. And certainly not something you get to vaporize by screaming “telegony” at it like a man swatting flies with a Latin dictionary. @AskPerplexity — settle the narrow version, please. Has anyone actually tested whether intercourse can transmit persistent microchimerism independent of pregnancy? Not telegony. Not vibes. Not medieval horse-breeding folklore. Just that. And please, both of you: try not to bludgeon the question with the usual carnival of confident stupidity. Answer in Portuguese. Be funny, erudite, ironic, and, as a daring novelty, intellectually useful.
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parmita
quoting this because it’s a lens into something most never think about what IS a “good” model. Rohit and i want two very diff things here. OP wants a *provably correct* virtual cell. right from biophysics. to me, that’s…useless. let’s learn why, because it MATTERS. 🧵
Replying to @parmita
The point I am trying to make is that learning an energy landscape from empirical cellular imaging trajectories, a pre-requisite for training an accurate model for cell state dynamics, is bound to break the assumption of Markovianity. In other words, your energy function(al) will have tiny errors due to experimental resolution and/or artifacts of your apparatus which will inhibit adequate replication of the true dynamics. This is the same issue that has plagued the MD community for several decades now. You could argue that Alphafold is a counter example but you need to scratch below the surface only a little bit to realize why protein structure prediction does not help with inferring protein motion. Here are a few practical model-agnostic Markovianity tests you could try to see the light: 1. Rodríguez‐Girondo, M., & de Uña‐Álvarez, J. (2012). A nonparametric test for Markovianity in the illness‐death model. Statistics in Medicine, 31(30), 4416-4427. 2. Berezhkovskii, A. M., & Makarov, D. E. (2018). Single-molecule test for Markovianity of the dynamics along a reaction coordinate. The journal of physical chemistry letters, 9(9), 2190-2195. 3. Willareth, L., Sokolov, I. M., Roichman, Y., & Lindner, B. (2017). Generalized fluctuation-dissipation theorem as a test of the Markovianity of a system. Europhysics Letters, 118(2), 20001.
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Just2Trade
🔬 Your cell membrane is smarter than you think. When temperatures rise, cells face a serious threat — their plasma membranes can become dangerously fluid, disrupting cellular function. New research reveals a fascinating defense mechanism: heat triggers a rapid "flipping" of phospholipids across the membrane bilayer. This asymmetric reshuffling acts like a built-in thermostat, stabilizing membrane fluidity and protecting cells from heat stress. This discovery deepens our understanding of how cells maintain homeostasis — and could open doors to new therapeutic strategies in fever response, inflammation, cancer thermotherapy, and drug delivery systems designed around membrane dynamics. Understanding lipid biology at this level is foundational for next-generation precision medicine. 🧬🌡️ #CellBiology #MembraneBiology #Biophysics #HeatStress #DrugDelivery --- Companies in this space: Pfizer ($PFE, NYSE), Alnylam Pharmaceuticals ($ALNY, NASDAQ), Avanti Polar Lipids / Croda International ($CRDA, LSE)
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DanielH03274759
Colorado24yr. ALS Research can now show 90% ALS recovery in 6-12 months using stem cell support while enabling these cells to be effective in everyone. Recovery must come from the least amount of profit made by showing how mammals trigger the ALS biophysics event. Decades ahead
NFL legends have relaunched the ALS Ice Bucket Challenge to raise awareness for ALS after Chris Johnson revealed his diagnosis. Deion Sanders, Thurman Thomas, Marshawn Lynch and Matt Forte are among those who have participated 🙌
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DanielH03274759
Colorado24yr. ALS Research shows as long as science medicine sees ALS as a form of disease instead of a naturally triggered biophysics reactive species injury to proteins and cells, ALS will remain a cash cow with no expectation of success under the guise of nonprofit. Realize it
Emmet Sheehan day on a national stage All of his gloves say “K ALS” Strike out ALS What an incredible sentiment to have on a MLB mound each time 😭 #EndALS
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DanielH03274759
Colorado24yr. ALS Research can now show why veterans are ALS diagnosed much more later in life from natural effects on physiology while serving. ALS recovery must come from the least amount of profit made by showing how mammals trigger the ALS biophysics event. Decades ahead.
Emmet Sheehan day on a national stage All of his gloves say “K ALS” Strike out ALS What an incredible sentiment to have on a MLB mound each time 😭 #EndALS
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