Senior Research Scientist @ ByteDance Seed | Prev @CMU_Robotics 🧬 Generative AI for science (DPLM) and computer vision 🤖 I share insights on AI & science

Joined June 2022
158 Photos and videos
🧬 Protein Autoregressive Modeling (PAR), ByteDance Seed We introduce PAR, the first multi-scale AR framework for protein backbone generation. Autoregressive modeling of 3D protein structures has long been considered difficult. Here’s how we make it possible with PAR. 👇 par-protein.github.io/
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PAR's oral and poster presentations are happening tomorrow at ICML. See you there! I'll also be giving a talk at the ByteDance booth. 🎤 Oral Presentation 📍 Hall D2 🕥 10:30–10:45 AM 🔗 icml.cc/virtual/2026/oral/71… 📌 Poster Presentation 📍 Hall A, #1413 🕑 2:00–3:45 PM 🔗 icml.cc/virtual/2026/poster/… 💡 Talk at the ByteDance Booth 📍 ByteDance Booth 🕓 4:00–4:30 PM Webpage: par-protein.github.io/ Code: github.com/bytedance-Seed/pa… Come chat about generative models, protein design, and AI for biology! #AI4S #ICML
🧬ICML 2026 Oral—Protein Autoregressive Modeling (PAR) Excited to share that PAR has been selected as ICML 2026 Oral. I will be in Seoul to present this work. Happy to connect and chat! 🥳 Autoregressive modeling of 3D protein structures has long been considered difficult. Here’s how we make it possible with PAR. 👇 par-protein.github.io
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wesley hsieh @ICML 2026 reposted
🧬ICML 2026 Oral—Protein Autoregressive Modeling (PAR) Excited to share that PAR has been selected as ICML 2026 Oral. I will be in Seoul to present this work. Happy to connect and chat! 🥳 Autoregressive modeling of 3D protein structures has long been considered difficult. Here’s how we make it possible with PAR. 👇 par-protein.github.io
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wesley hsieh @ICML 2026 reposted
Don't understand all the AI jargon everyone around you keeps saying? You're welcome, I made the updated AI dictionary 🥳🥳- : - The bitter lesson - scale beats everything else, especially your clever idea - Brain-inspired - we read one neuroscience abstract in 2019 - AGI - whatever the current models can't do yet - Superintelligence - AGI, but the last name was taken - Self improvement - letting a coding agent run your experiments - Recursive self improvement - the same thing but it sounds more impressive - RL - it works now, we just don't know why this time - Memory - a text file the agent appends to - Continual learning - solved next year, every year since 2016 - Agent framework - the same model prompted five different ways and called a team Novel architecture - a transformer - Frontier model - our model - Technical report - a paper with the methods section removed - Emergent capabilities - a metric we didn't plot until it went up - Neolab - a bunch of ex-{Meta, OpenAI, GDM} people who think they know better - We fired because of AI - we did not fire because of AI - We're hiring - we raised Hope this helps. See you in the next edition, the field should generate enough new terms by Friday!
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The codebase and model checkpoints are now open source. Give them a try! Webpage: par-protein.github.io/ Model checkpoints: huggingface.co/collections/B… Codebase: github.com/bytedance-Seed/pa…
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🤝 Sincerely appreciate and big congrats to all the authors: Yanru Qu, @chengyenhsieh (Project Lead), @zaixiang_zheng, @GeLiuSaber, and @QuanquanGu
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Besides the results above, we additionally quantified the zero-shot motif scaffolding results to present a more comprehensive evaluation.
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Worth mentioning again, since PAR handles multiple granularities, a human can specify a coarse layout (e.g., just 16 points) and the model will generate a complete, structurally consistent protein backbone. No fine-tuning required!
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For a quick overview, check this thread: x.com/chengyenhsieh/status/2…
🧬 Protein Autoregressive Modeling (PAR), ByteDance Seed We introduce PAR, the first multi-scale AR framework for protein backbone generation. Autoregressive modeling of 3D protein structures has long been considered difficult. Here’s how we make it possible with PAR. 👇 par-protein.github.io/
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wesley hsieh @ICML 2026 reposted
Introducing Claude Science, a new app designed with every stage of research in mind. Artifacts traced to their code, environments managed on demand, and 60 optional scientific databases that you can connect. Available now in beta.
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The talent density of computer vision researchers at ByteDance is real.
Bytedance is dropping the best video gen model in the world in early July: Seedance 2.5! The video below (audio on) is the launch video from their Volcano Engine conference this week. It cements China’s absolute dominance in video. — 2x’d generation length of all previous models to 30s, with audio 4k video — >5x’d reference images / audio / video to 50 — Allows localized editing (specific characters, closing, detail), will come with copyright filter Seedance 2 is already the #1 video model and does a whopping $2B in ARR, in a mere 4.5mos! At the current pricing of $2.5/15s, that implies >3.3M hours of video (!) have been generated. That’s 3x every feature film ever made and dozens of Netflixes. Only 3 US AI startups make more revenue. We are 2x’ing realistic video gen length every 6mos. — May 2025: Veo 3 does audio video for the first time, 15s — Jan 2026: Kling 3 does 15s — Feb 2026: Seedance 2 does 15s, big quality bump — July 2026: 2.5 will do 30s In 18mos, entire music videos will be oneshotted by AI. China continues to extend its lead on video models vs America.
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These companies are testing my English vocabulary with all the new model names coming. Let me propose another one: GPT- Pneumonoultramicroscopicsilicovolcanoconiosis (a theoretical lung disease)
Introducing a limited preview of GPT-5.6 Sol, our next generation frontier model, as well as GPT-5.6 Terra, a balanced model for efficient, everyday work, and GPT-5.6 Luna, a fast and affordable model for high-volume work. openai.com/index/previewing-…
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How scaling laws were developed overtime
A super long overdue (3 years?) post on scaling laws. Compute is expensive. Scaling laws are a way to help us reason about the optimal compute allocation between data and model size before committing to a large run. The post covers what scaling laws predict, how compute-optimal allocation works, why Kaplan et al. and Chinchilla disagree, and how data limits fitting details make extrapolation tricky. lilianweng.github.io/posts/2…
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Tips for interview preparation are great, but the premise to make things work is that your research records are as impressive as Alisa’s 💀 Companies can suddenly reject you for no reason even if you perform reasonably well in all interviews.
I'm joining OpenAI next week!🥹 The job search turned out to be really challenging but also super rewarding, so I wrote a small blog to share what I learned along the way and hopefully make the process a little less mysterious for the next person. alisawuffles.github.io/blog/…
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Imagine someone named Claude is in your team
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Feels like an interesting research/project direction
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x.com/askalphaxiv/status/206…
Introducing autoresearch for GitHub repos Change 'Github' to 'ARGithub' in any repo URL Research artifacts extend beyond papers. Autoresearch is especially useful for experimenting on existing codebases that move fast and outpace their own publications. With one URL change you can now deploy an agent to orient itself on the codebase, resolve setup issues, and iterate on experiments.
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$200M seed round? The pace at which seed-round sizes have grown is incredible. They will likely lead a $200B seed round in 2030.
We're thrilled to lead Mirendil's $200M seed round. Frontier AI work has been locked inside a few big labs. @mirendil is building a system that can help anyone do AI work: they train frontier models that are expert at AI R&D and build the product around it. The result is a system that loops over research and engineering problems on its own, making progress without human intervention. It's like a coding agent built for AI research that controls its own GPUs. Mirendil is one of the few teams with the experience and the priors to make the end-to-end system work. @bneyshabur, @HarshMeh1a, @shayan_, and @tararezaeikh come out of Anthropic, Google DeepMind, and xAI. Welcome to the a16z family, Mirendil. By @BornsteinMatt and @MaikaThoughts
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