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bioRxiv Bioengineering @bioRxiv_bioE

Bioengineering preprints | not affiliated with bioRxiv | maintained by @MichaelRetchin

Joined April 2021
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Estimating Body Segment Properties for Adults AcrossDiverse Body Morphologies: A Data-Driven GeometricFramework ift.tt/OsNBLjK #biorxiv_bioE

Estimating Body Segment Properties for Adults Across Diverse Body Morphologies: A Data-Driven...

Accurate estimation of body segment inertial properties is essential for biomechanical analyses, yet commonly used scaling methods rely on limited datasets and do not generalize well across diverse...

biorxiv.org
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Water as a thermal contrast agent for artificial-intelligence-enhanced in vivo mid-infrared thermography ift.tt/lymEwXQ #biorxiv_bioE

Water as a thermal contrast agent for artificial-intelligence-enhanced in vivo mid-infrared...

In vivo infrared thermography is limited by the inherently poor spatial resolution at long wavelengths, low contrast, and the lack of biocompatible contrast agents. Here, we present 3-5 μm mid-wave...

biorxiv.org
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Combined computational and experimental analysis confirm donor-dependent optimization of critical processing parameters for improving mesenchymal stromal cell potency and expansion attributes ift.tt/oTWK3Dr #biorxiv_bioE

Combined computational and experimental analysis confirm donor-dependent optimization of critical...

Mesenchymal Stromal Cells (MSC) face several heterogeneity challenges hindering clinical and commercial success. Employing a multiple response model, interplay between donor heterogeneity, and...

biorxiv.org
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Residual Hair Biomaterial Particulates Improve Dermal Regeneration and Combined with Electrical Stimulation Accelerates Skin Wound Closure ift.tt/SxrJvck #biorxiv_bioE

Residual Hair Biomaterial Particulates Improve Dermal Regeneration and Combined with Electrical...

Objective: To evaluate the effect of residual hair (RH) biomaterial particulates, biphasic electrical stimulation (ES), and their combination (RHES) on the kinetics and quality of skin wound healing....

biorxiv.org
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Fibroblasts impair muscle stem cell self-renewal via excessive fibronectin deposition in viscoelastic hydrogel co-cultures ift.tt/JBiw194 #biorxiv_bioE

Fibroblasts impair muscle stem cell self-renewal via excessive fibronectin deposition in viscoela...

Muscle satellite cells (SCs) regenerate skeletal muscle, but their regenerative capacity declines with age, in part due to extracellular matrix (ECM) remodeling and aberrant fibroblast activation...

biorxiv.org
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Multi-Site Reproducibility Study of 3D High-Content Analysis with Dual-View Oblique Plane Microscopy ift.tt/gMy2nmF #biorxiv_bioE

Multi-Site Reproducibility Study of 3D High-Content Analysis with Dual-View Oblique Plane Microscopy

High content imaging is being applied to achieve quantitative fluorescence readouts in increasingly complex 3-dimensional (3D) cell culture models such as spheroids and organoids. Compared to...

biorxiv.org
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L-5--glutamine PET of Breast Cancer: Kinetic Analysis in Mouse Models to Evaluate Glutamine Metabolism ift.tt/4mhY9NB #biorxiv_bioE

L-5-[11C]-glutamine PET of Breast Cancer: Kinetic Analysis in Mouse Models to Evaluate Glutamine...

Abstract (250 words) Background: Glutamine addiction is a hallmark of aggressive tumors, yet glutaminase (GLS1) inhibitor CB-839 showed disappointing anti-tumor efficacy in clinical trials. L-5-[11...

biorxiv.org
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Time-of-flight-resolved interferometric speckle-contrast optical spectroscopy (TOF-iSCOS) for depth-resolved blood-flow sensing ift.tt/DBIqUb6 #biorxiv_bioE

Time-of-flight-resolved interferometric speckle-contrast optical spectroscopy (TOF-iSCOS) for...

Significance: Continuous, noninvasive, and depth-resolved monitoring of blood-flow-related tissue dynamics remains an important unmet need. Speckle-contrast optical spectroscopy (SCOS), including...

biorxiv.org
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Bioorthogonal Tuning of Hydrogel Stiffness Promotes Zonal Redifferentiation of Passaged Chondrocytes ift.tt/AdUNTnu #biorxiv_bioE

Bioorthogonal Tuning of Hydrogel Stiffness Promotes Zonal Redifferentiation of Passaged Chondrocytes

Generating bioengineered cartilage that recapitulates the depth-dependent phenotype, structure, and function of native articular cartilage remains a challenge. While cartilage is rich in aggrecan and...

biorxiv.org
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Fucoidan-Coated Layer-by-layer Lipid Nanoparticles for the Generation of CAR-Macrophages ift.tt/omFOEDs #biorxiv_bioE

Fucoidan-Coated Layer-by-layer Lipid Nanoparticles for the Generation of CAR-Macrophages

Modulation of immune cells as therapeutic tools has gained significant clinical relevance in the treatment of cancer. Among them, macrophages represent a promising immunotherapeutic platform not only...

biorxiv.org
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Effects of Tempo, Dynamics, and String on Physical Exposure in Professional Violinists ift.tt/CEza3p2 #biorxiv_bioE

Effects of Tempo, Dynamics, and String on Physical Exposure in Professional Violinists

This study examined how tempo, dynamics, and string influence upper-extremity physical exposure in professional violinists and how exposure variability is distributed among musical characteristics,...

biorxiv.org
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Particle size determines mucociliary transport mechanisms in normal and cystic fibrosis airways ift.tt/bmPYJ86 #biorxiv_bioE

Particle size determines mucociliary transport mechanisms in normal and cystic fibrosis airways

A wide spectrum of microparticles is inhaled with each breath, deposited on airway surfaces, entrapped in the mucus, and removed by mucociliary transport (MCT). However, the influence of particle...

biorxiv.org
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Assessing the Relative Impact of Grasp and Object on Inferior Frontal Gyrus Activity during a Grasping Task ift.tt/48meFks #biorxiv_bioE

Assessing the Relative Impact of Grasp and Object on Inferior Frontal Gyrus Activity during a...

The lateral grasp network, responsible for translating visual properties of an object to execution of a motor act, is comprised of the anterior intraparietal area (AIP), area F5, and the primary...

biorxiv.org
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APRIL: Adaptive Regression-Based Two-Dimensional Quantitative Anisotropy Imaging Using Acoustic Radiation Force Impulse ift.tt/gF4GZwl #biorxiv_bioE

APRIL: Adaptive Regression-Based Two-Dimensional Quantitative Anisotropy Imaging Using Acoustic...

Objective: This study aims to develop and validate a quantitative, depth-resolved anisotropy imaging framework that extends ARFI-based focal degree-of-anisotropy (DoA) estimation into two-dimensional...

biorxiv.org
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Rationally Anchored Geometry-Controlled DNA Tetrahedral Nanostructures for Attomolar Impedimetric IL-6 Detection ift.tt/hOc0AeJ #biorxiv_bioE

Rationally Anchored Geometry-Controlled DNA Tetrahedral Nanostructures for Attomolar Impedimetric...

Interleukin-6 (IL-6) is a pleiotropic cytokine whose aberrant elevation drives life-threatening conditions, including sepsis, cytokine storm, and autoimmune disorders, yet existing clinical detection...

biorxiv.org
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Multimodal 3D light-field and laser-speckle endoscopy ift.tt/OCM41tV #biorxiv_bioE

Multimodal 3D light-field and laser-speckle endoscopy

Minimally invasive surgery is a powerful technique that enables operations deep within the body while minimizing patient trauma and recovery time. Optical endoscopes are key to providing intraopera...

biorxiv.org
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In Vitro Detection of Breast Cancer Cell Types Using Machine Learning-Assisted Spectral Fingerprinting of SWCNTs ift.tt/PsKcar8 #biorxiv_bioE

In Vitro Detection of Breast Cancer Cell Types Using Machine Learning-Assisted Spectral Fingerpri...

The early detection of breast cancer currently relies on expensive mammography, followed by pathology that uses biopsied, fixed, and immunohistochemically stained tissues. A live-cell detection...

biorxiv.org
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Electrophysiological profiling of hiPSC-derived neurospheres using a novel NeuroMPS with integrated electrodes ift.tt/Q1ngRLB #biorxiv_bioE

Electrophysiological profiling of hiPSC-derived neurospheres using a novel NeuroMPS with integrated...

The increasing prevalence of neurological disorders highlights the need for human in vitro systems that recapitulate key mechanisms of neurodegeneration and neuroinflammation. Although induced...

biorxiv.org
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Safe Redosable Low-Immunogenic In Vivo CAR-T Therapy for B Cell Malignancies and Solid Tumors ift.tt/hsy7cCX #biorxiv_bioE

Safe Redosable Low-Immunogenic In Vivo CAR-T Therapy for B Cell Malignancies and Solid Tumors

In vivo CAR-T cell therapy eliminates manufacturing complexities associated with ex vivo autologous approaches, but safety concerns have limited adoption. We developed viroVbot, a next-generation in...

biorxiv.org
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A Pubic Hair Is 172 Times More Pubic Than a Scalp Hair ift.tt/7UqribY #biorxiv_bioE

A Pubic Hair Is 172 Times More Pubic Than a Scalp Hair

Human hair is a common contaminant in GMP-controlled manufacturing environments, and its identification is important for contamination source investigation and corrective action. Because human hair...

biorxiv.org
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