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Nature Biotechnology @NatureBiotech

Publishing the best of biotech science and business. Find us on Bluesky, Facebook & Instagram. Part of @SpringerNature and @NaturePortfolio.

Joined June 2009
  • Posts 17,217
  • Following 2,671
  • Followers 324,172
4,718 Photos and videos
Nature Biotechnology reposted
Rong @_RongL
Jul 3
The brief digital edition of @NatureBiotech’s June issue is live now! Check it out here: mp.weixin.qq.com/s/eXJfskj-p…
Nature Biotechnology
 @NatureBiotech
Jun 16
The June issue is live nature.com/nbt/volumes/44/is… The cover shows an illustration of vascularized tumors on a chip. Liu et al. present a long‑term, perfused system for human solid tumors that supports CAR‑T delivery and real‑time analysis of tumor–CAR‑T dynamics, evaluation of engineering strategies, and identification of druggable targets go.nature.com/3Jc62gv rdcu.be/foISS
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Nature Biotechnology reposted
Xue Sherry Gao @XueSherryGao
Jun 30
Excited to share our latest work, now published in @NatureBiotech! We established the first prime editing platform for filamentous fungi, achieving average editing efficiencies approaching 90% across diverse loci and species. nature.com/articles/s41587-0…

Prime editing for precise genome engineering and modulation of fungal metabolism

Nature Biotechnology - fPE7max efficiently installs base substitutions, insertions and deletions to modulate filamentous fungal metabolism.

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Nature Biotechnology reposted
Jeff Miller @wraithnot
Jun 29
We are thrilled that an article describing our #MINTplatform has just been published in @NatureBiotech!: nature.com/articles/s41587-0…

Retargeted serine integrases for one-step, precise integration of large DNA sequences in human cells

Nature Biotechnology - Serine integrases are retargeted to streamline genomic integrations of DNA.

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Nature Biotechnology reposted
Sanketh Vedula @sankethvedula
Jun 29
Excited to share that experiment-guided AlphaFold is now published in @NatureBiotech!
Nature Biotechnology
 @NatureBiotech
Jun 29
Experiment-guided AlphaFold3 resolves measurement-consistent protein ensembles nature.com/articles/s41587-0…
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Retargeted serine integrases for one-step, precise integration of large DNA sequences in human cells nature.com/articles/s41587-0…
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A retargeted recombinase for precise insertion of large DNA #NBTNV nature.com/articles/s41587-0…
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An evaluation framework isolates perturbation-specific effects in perturbation datasets go.nature.com/4791kda rdcu.be/fpOWU

Systema: a framework for evaluating genetic perturbation response prediction beyond systematic...

Nature Biotechnology - An evaluation framework isolates perturbation-specific effects in perturbation datasets.

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The New Clinical Investigation exclusivity: a substantial source of monopoly time for brand drugs bit.ly/3T9fjYg
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Methodological concerns and a lack of evidence for reforming regulatory exclusivities for pharmaceuticals nature.com/articles/s41587-0…

Methodological concerns and a lack of evidence for reforming regulatory exclusivities for pharmac...

Nature Biotechnology - Methodological concerns and a lack of evidence for reforming regulatory exclusivities for pharmaceuticals

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Reply to ‘Methodological concerns and a lack of evidence for reforming regulatory exclusivities for pharmaceuticals’ nature.com/articles/s41587-0…

Reply to ‘Methodological concerns and a lack of evidence for reforming regulatory exclusivities for...

Nature Biotechnology - Reply to ‘Methodological concerns and a lack of evidence for reforming regulatory exclusivities for pharmaceuticals’

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Each year, we highlight companies that received sizeable early-stage funding in the previous year. Trogenix has developed a platform for generating ‘synthetic super-enhancers’ that could drive highly cell-specific gene therapy-based treatment of solid tumors such as glioblastoma nature.com/articles/s41587-0…
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A plug-and-play system fine-tunes multiple targets simultaneously for secondary metabolite production in Streptomyces go.nature.com/3HdTOTV rdcu.be/fpOVH

Scalable secondary metabolite production in Streptomyces using a plug-and-play system

Nature Biotechnology - A plug-and-play system fine-tunes multiple targets simultaneously for secondary metabolite production in Streptomyces.

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With endless curiosity and persistence, this biologist is motivated by the prospect of developing stem cell technologies that could one day repair damaged organs or even create new organs for transplantation nature.com/articles/s41587-0… rdcu.be/fpQOo

Five questions with Ya-Wen Chen

Nature Biotechnology - With endless curiosity and persistence, this biologist is motivated by the prospect of developing stem cell technologies that could one day repair damaged organs or even...

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Experiment-guided AlphaFold3 resolves measurement-consistent protein ensembles nature.com/articles/s41587-0…
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Toward experiment-guided AlphaFold: @ISTAustria researchers enhance Nobel Prize-winning structural prediction model #NBTintheNews ist.ac.at/en/news/toward-exp…

Toward Experiment-Guided AlphaFold

The AI-based program AlphaFold predicts a protein’s 3D structure with remarkable accuracy. However, it tends to reduce heterogeneous structures to a single dominant conformation, or shape, and...

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Biotech news from around the world: United Kingdom, Vietnam, United Arab Emirates, Brazil, Japan nature.com/articles/s41587-0… rdcu.be/frxni
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A genome-scale CRISPRi perturbation atlas of human induced pluripotent stem cells nature.com/articles/s41587-0…
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Genomic integration of DNA templates is made more precise through microhomology-focused design go.nature.com/41GoBiX rdcu.be/fpOUC

Precise, predictable genome integrations by deep-learning-assisted design of microhomology-based...

Nature Biotechnology - Genomic integration of DNA templates is made more precise through microhomology-focused design.

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Large-scale, spatially resolved panoramic CRISPR screening in native tissue environments using Perturb-DBiT nature.com/articles/s41587-0…
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Spatial CRISPR screening just made your preclinical models look like guesswork #NBTintheNews via @ctrialvanguard clinicaltrialvanguard.com/op…

Spatial CRISPR Screening Just Made Your Preclinical Models Look Like Guesswork

Nature Biotechnology's Perturb-DBiT maps CRISPR perturbations in native tissue — and exposes why dissociated-cell screens keep producing trials that fail in…

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Spatial CRISPR unveils RNA roles in tumor growth and immunity #NBTintheNews via @YaleCancer medicine.yale.edu/cancer/pub…

Spatial CRISPR Unveils RNA Roles in Tumor Growth and Immunity

This study introduces Perturb-DBiT, a method enabling spatially resolved CRISPR screens and transcriptomics in tissues, uncovering genetic and RNA-level

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Recent patents relating to methods and systems for using artificial intelligence in drug discovery nature.com/articles/s41587-0… rdcu.be/frihO

Artificial intelligence in drug discovery

Nature Biotechnology - Recent patents relating to methods and systems for using artificial intelligence in drug discovery.

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Prime editing for precise genome engineering and modulation of fungal metabolism - @XueSherryGao @DrYihuiShen nature.com/articles/s41587-0…
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Mass spectrometry and wearable sensor technology are complementary approaches that, when integrated, can co-evolve to open new possibilities for noninvasive health monitoring go.nature.com/4rvOjAS rdcu.be/fpQNs

Biomolecular profiling for noninvasive health monitoring

Nature Biotechnology - Kim et al. present mass spectrometry and wearable sensor technology as complementary approaches that, when integrated, can co-evolve to open new possibilities for noninvasive...

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Spatially resolved profiling of extracellular vesicles in tissues with Spatial-EV-seq nature.com/articles/s41587-0…
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Research Briefing: Mapping the spatial landscape of extracellular vesicles in tissues with Spatial-EV-seq nature.com/articles/s41587-0… rdcu.be/fq1cg

Mapping the spatial landscape of extracellular vesicles in tissues with Spatial-EV-seq

Nature Biotechnology - Spatial-EV-seq is a method for spatially resolved profiling of extracellular vesicles (EVs) in tissues while preserving EVs’ native distribution. By integrating EV...

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