Spermidine is quietly becoming one of the most studied longevity compounds of the decade.
It activates autophagy, the process where cells break down and recycle damaged components. That mechanism alone has extended median lifespan by roughly 10% in animal models.
In humans, high dietary spermidine intake correlates with 24% lower all-cause mortality, 27% lower cognitive impairment risk, and 47% lower Alzheimer risk according to epidemiological data.
Clinical trials use 1.2-5 mg per day. At that range, studies show improved memory scores in adults over 65, reduced CRP and IL-6 inflammation markers, and lower arterial stiffness after 12 months.
For supplementation, a size 1 HPMC capsule works well. Wheat germ extract standardized to 1-3 mg is the most studied form. HPMC over gelatin for moisture stability and vegan compatibility.
Natural sources: wheat germ, aged cheese, fermented soy, natto.
Large-scale human trials are ongoing to confirm optimal dosing ranges.
#Spermidine #Longevity #Autophagy #Supplements
