Building for The New Regulatory Paradigm | Resident @theresidency (Biopunk S26)

Joined December 2025
25 Photos and videos
Big believer in multi-generational co founding and grateful for the founding team of Omnalis spanning ages 27 to 67!
The age of the 40-year-old founder is back. Bryant Chou spent 12 years as CTO of Webflow, which now powers something like 1.5% of the entire internet. He's back in the current YC batch with Ploy, an AI marketing platform, and he describes himself as "a bit of a boomer, double the age of the YC founders." But over 13% of his batch is already using his product, within months of launch. There is a side of the argument which destroyed one of the main edges young founders have, which was being faster and cheaper at building.... speed is everyones game. If what's left is knowing what to build this is more likely to come from spending 15 years watching an industry up close, collecting the thousand small frustrations that tell you where the real problem is. Bryant can build an anti-slop website tool because he spent over a decade learning exactly why websites are slop. So I'm updating. I don't think it's young vs. old. I think AI rewards whoever has the most domain knowledge to point it at, and only sometimes is this younger founders who are thinking outside of the box...
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Grateful for third spaces in the midst of chaos @BiopunkLab @theresidency
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Yes, thats a latte, and yes its 10:30pm šŸ˜
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Truly don’t know what I’d do without Trudy at this hour @UseCorgi
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The only way to deactivate energy activation hurdles is to stare it down straight in the face, embrace the cause of the fear itself, and surround yourself with accountability buddies. Grateful for @theresidency and @LongJourneyVC residencies for making this process a possible feat for founders.
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The constant oscillation of a founder, sprinting and marathon training, reminds me a lot of the diminishing return effect of my rowing days, on repeat.
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We’re entering a labyrinth of confusion in AI for Life Sciences as models sprint towards a wall of reasoning accountability. Traceable, validated, operationalized, and trusted model outputs embedded inside regulated workflows still don’t exist.
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Liz Wells reposted
This vial contains a new drug called PAC-832, which I recently invented to treat Alzheimer’s disease. It is the world’s first selective GalR1 antagonist. I designed and synthesized PAC-832 in a chemistry lab I built in my garage. (1/16)
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Today, the first LLM was approved by the FDA. We’re entering an era where population health is becoming solvable. and the frontier will ā€œset the tone for efficacy of continuous care coordination and bend the curve on some of the most persistent challenges in population health." Desi Kotis, UCSF Health & vice dean of clinical affairs at UCSF School of Pharmacy
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Liz Wells reposted
I have so much respect for Collisons- always hit the nail with what society needs. Billionaires we do need.
We're launching Intercept, a new philanthropic initiative to fight respiratory viruses like colds and flus. interceptfund.com/
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Liz Wells reposted
In another preprint from the @brianhie Lab and @SynBioGaoLab, they introduce Germinal, a generative AI system for de novo antibody design. Germinal produces functional nanobodies in just dozens of tests, making custom antibody design more accessible than ever before.
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Yesterday’s demo day with @LongJourneyVC @EdgeEsmeralda @JoinEdgeCity was a dual celebration. Unlocking the next chapter of building with my peers. And the next chapter of sobriety. It’s amazing how much can change in two years. Thank you @LeeJacobs @cyantist @zmwang @carolenaleon @LeeJacobs @jwmares @ariellezuck and the rest of the magically weird crew for giving us a life changing playground. I’ll cherish these early days forever.
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DEMO DAY IS IN 1 DAY AHHHHH alternate title: @LeeJacobs giving us residents some spirited feedback and advice
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The multidisciplinary musings from the AI Salon we hosted last week: - There is a deeper tension between privacy and innovation in health & data systems. - Real progress will likely come from incremental advances in interfaces, institutions, & the ways new ideas are tested, trusted, & brought to scale. @JoinEdgeCity @EdgeEsmeralda
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Liz Wells reposted
slop is a trillion dollar problem
We’re excited to introduce Taste Labs. Our mission is to end AI slop. We’re building the data and infrastructure layer to give AI models and agents taste. And today we’re coming out of stealth, announcing our $18.5M seed funding, co-led by @CRV and @AmplifyPartners AI has nailed objective domains and made it easy to generate anything. But it still feels off. Now, the challenge is judgement. What fits, what feels like you, what’s GREAT. This requires turning a fuzzy, subjective domain into something we can measure and codify. We’re starting with design. There are two sides to cracking this, the foundation model layer and the agent layer: - We’ve already been working with the top frontier labs to evaluate and improve their models, crafting the right post-training data and RL environments. - We’ve also been working with app-layer companies to build the context and verification tools for their agents to produce better, more on-brand, more creative outputs. We want a future where AI feels right. If you’re passionate about this mission, join us!
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Liz Wells reposted
Just heard of a startup that spent $100,000 on their launch dinner. Early Amazon used doors as desks to save money, frugality wins and wasting money loses! Early corgi had a free furniture rule and our early engineers spent their work trials collecting furniture from all the startups that went under.
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Liz Wells reposted
Each day saved before first-in-human studies is worth~$1 M to a pharma company, in net present value:
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The new FDA paradigm is here. Or is it? Link in the comments
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