Joined April 2016
316 Photos and videos
Pinned Post
A tweetorial on our study (gastrojournal.org/article/S0…). But, first a case: Young female w/ a 1.9 cm incidental pancreatic cyst. No concerning features, but KRAS, TP53 and SMAD4 mutations on molecular testing. Surgical resection: #IPMN w/ a small #PancreaticCancer. #Pathology #GIPath
12
158
329
Aatur Singhi, MD PhD reposted
First day of residency ✅ Excited to trade in my stethoscope for a microscope with the best people 🔬 @UPMCPath @UPMCPathology
2
3
49
5,076
Aatur Singhi, MD PhD reposted
Add NRG1 fusions to the list of targetable alterations in cholangiocarcinoma. 🔹 Zenocutuzumab is now FDA-approved for NRG1-fusion positive cholangio 🔹 RNA NGS >>> DNA NGS for detecting NRG1 fusions. Best practice: order both for all cholangio pts doi.org/10.1200/JCO-25-03128
3
14
27
3,633
Aatur Singhi, MD PhD reposted
YAY!!! Huge congrats to previous team @UMich and our entire team @PittTweet @PittDeptofMed 👏👏👏. Most importantly, all our authors, reviewers, readers and team @the_asci.
📣We're proud to announce an increase in JCI Insight's impact factor to 6.8 (from 6.1, 2024) . Thank you authors, reviewers, and readers!
3
11
1,638
Aatur Singhi, MD PhD reposted
Great colleague Rong Fan led a team of experts at Yale, Hopkins, and UCSD to write a review on 3D multi-comics of tissues and tumors. Check it out: nature.com/articles/s41568-0…
2
17
81
7,099
Aatur Singhi, MD PhD reposted
That's a lot of spatial human proteomics! >13,000 proteins ~3,0000 samples 58 major tissues types 25 cancer types nature.com/articles/s41586-0…
9
163
501
43,371
Aatur Singhi, MD PhD reposted
Join us in Minneapolis, MN for @CAPERpancreas #PacreasFEST26 We are debating pancreas cyst fluid analysis prior to surgery when worrisome features are present on imaging! @PancPathologist #DavidWeinberg @NatPancFdn @apapancreas @MaisamHaijaMD @PittGILiverNutr @CCF_GIFellows
3
21
1,015
Aatur Singhi, MD PhD reposted
The House Appropriations Committee passed its version of the FY27 spending bill, including an increase of $110 million compared to the current year’s budget for @theNCI 👏🏽👏🏽 From @TheCancerLetter cancerletter.com/capitol-hil… The Senate will now take up its version of appropriations.
1
11
54
5,177
Aatur Singhi, MD PhD reposted
Papillary adenocarcinoma of head of pancreas, with metastases to common bile duct and lung @NEJM 1946 Case records of MGH. Probably one of the first descriptions of what we would now call as #PancreaticCancer arising in a main duct intraductal papillary mucinous neoplasm (IPMN).
1
2
17
1,511
Aatur Singhi, MD PhD reposted
Hopkins will provide $280M in mid-size and large grants to support faculty for 2 years (1) $160M for all life scientists (from basic to translation) (2) $120M for all science and engineering. This cannot replace federal funding, not even close, but it helps.
5
52
316
24,445
Aatur Singhi, MD PhD reposted
🤩 spatial panoramic in vivo CRISPR screen via Perturb-DBiT 🤩 Excited to share our collaborative work with @sidichen lab and many outstanding collaborators, now published in Nature Biotechnology! nature.com/articles/s41587-0…
3
62
243
18,385
Aatur Singhi, MD PhD reposted
PanCAN's Chief Scientific and Medical Officer, Dr. @ABerkenblit, shares, "I know that in the years to come, we'll look back on this year's #ASCO26 meeting as marking the beginning of a new era for patients with pancreatic cancer. As a long-standing American Society of Clinical Oncology (ASCO) member, it was a privilege this year to attend alongside my colleagues from Pancreatic Cancer Action Network, knowing the pivotal role PanCAN played to get us to this historic moment, and that the community is looking to PanCAN to help us all make good on the promise that RAS therapies hold for patients with pancreatic cancer. Unprecedented indeed are the Phase 3 data for #daraxonrasib, a RAS-targeted therapy developed by Revolution Medicines and presented by Dr. Brian Wolpin. These highly anticipated data were received with wild enthusiasm — a standing ovation! — from the ASCO community. Overall survival and progression-free survival were ~doubled, and overall response rate was ~tripled with daraxonrasib compared with chemotherapy in patients with previously treated metastatic pancreatic cancer, with all subgroups benefiting. Importantly, quality of life and pain were improved, so that patients not only live longer, but also feel better — just what we want from new therapies. Optimal management of side effects, including rash and mouth sores, is paramount to maximize the benefit — and PanCAN Patient Services is ready to embrace the educational needs!" Learn more about the additional data released on daraxonrasib and this significant advance for #pancreaticcancer treatment at 🔗 pcan.at/rjul9sza.
8
18
942
Aatur Singhi, MD PhD reposted
Important research shared by Dr. Diwakar Davar (@diwakardavar) at #ASCO26 on a PRAME-directed T-cell therapy for patients with advanced melanoma. The research showed meaningful responses in patients with limited treatment options, highlighting a promising approach for difficult-to-treat melanoma. @UPMCHillmanCC #ASCO26 #MoffittASCO26
3
20
1,130
Aatur Singhi, MD PhD reposted
Multi-omics approaches are unravelling the complex biological landscape of pancreatic #NETs Building on this collective effort, we have integrated this remarkable body of knowledge into a comprehensive overview rdcu.be/flQyn @PancPathologist @VolkanAdsay @Chris_Heaphy
1
3
9
997
Aatur Singhi, MD PhD reposted
Incredible #ASCO26 moment. Dr. Brian Wolpin, presenter of the daraxonrasib study, received a standing ovation DURING his talk after he stated the survival benefit for PDAC patients. It was sustained. Cheering. I have never see anything like it in the middle of a talk. $RVMD
16
136
987
155,945
Aatur Singhi, MD PhD reposted
Next up is the one and only @OncoThor discussing emerging targets in pancreatic NETs. #ASCO26
6
21
815
Aatur Singhi, MD PhD reposted
Presented at #ASCO26: Among patients with previously treated metastatic pancreatic ductal adenocarcinoma, the RAS(ON) inhibitor daraxonrasib led to significantly longer overall survival and progression-free survival than chemotherapy. Full phase 3 RASolute 302 trial results: nej.md/4nWaxvM @ASCO
53
2,057
5,592
2,509,260
Aatur Singhi, MD PhD reposted
A warm #ASCO26 welcome to daraxonrasib and RASolute-302 study in 2nd line metPDAC from $RVMD My story in the post below. Here are the OS curves you haven't seen yet.
10
47
250
99,083
Aatur Singhi, MD PhD reposted
The overall survival curves for Daraxonrasib in 2nd line advanced #PancreaticCancer leave no doubt how impactful this advance is for the field & for patients. Congratulations Brian Wolpin, @EileenMOReilly & @md_oberstein et al. A seminal #ASCO26 plenary! nejm.org/doi/full/10.1056/NE…
2
64
202
14,652