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Cell Stem Cell @CellStemCell

A monthly journal at the forefront of stem cell science and policy. Posts & opinions from Editor-in-Chief, Dr. Sheila Chari

Joined June 2009
  • Posts 9,961
  • Following 69
  • Followers 59,237
1,825 Photos and videos
Human stem cell-based embryo model governance: Insights from Japan dlvr.it/TTLYhD

Human stem cell-based embryo model governance: Insights from Japan

Despite rapid advances in human stem cell-based embryo model (SCBEM) research, national regulatory frameworks remain limited. On April 1, 2026, Japan implemented revised guidelines extending their...

cell.com
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Psychological stress drives aging-like hematopoietic stem cell dysfunction through a brain-gut-bone marrow axis dlvr.it/TTLVHl

Psychological stress drives aging-like hematopoietic stem cell dysfunction through a brain-gut-bone...

Zhao and colleagues show that psychological stress impairs hematopoietic stem cell function through a brain-gut-bone marrow axis. Stress-responsive neural circuits remodel the intestinal environment...

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Quantitative molecular cartography of emergency myelopoiesis reveals conserved modules of hematopoietic activation dlvr.it/TTLRpM

Quantitative molecular cartography of emergency myelopoiesis reveals conserved modules of hematop...

Swann et al. conducted a comparative analysis of single-cell RNA-sequencing data from emergency myelopoiesis models, finding that different perturbations act at distinct levels of the hematopoietic...

cell.com
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Paired pre- and post-transplant human immunoprofiling identifies an IFN-γ-JAK1 axis limiting stem-cell-derived RPE engraftment dlvr.it/TTLJNF

Paired pre- and post-transplant human immunoprofiling identifies an IFN-γ-JAK1 axis limiting...

Gao et al. identify a Th1-biased, IFN-γ-rich immune state that reprograms hESC-RPE immunogenicity through JAK1 signaling. Brief ex vivo ruxolitinib conditioning dampens HLA induction and immune...

cell.com
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ENPP1 blockade with a humanized monoclonal antibody enhances renal repair after acute kidney injury dlvr.it/TTKgDJ

ENPP1 blockade with a humanized monoclonal antibody enhances renal repair after acute kidney injury

Deb and colleagues identify ENPP1 as a critical negative regulator of kidney regeneration. They demonstrate that targeting ENPP1 using a novel humanized monoclonal antibody enhances tubular cell...

cell.com
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ZNF512B safeguards genome integrity at regulatory regions to repress the SASP and inflammation dlvr.it/TTKdMN

ZNF512B safeguards genome integrity at regulatory regions to repress the SASP and inflammation

Belmonte and colleagues show that ZNF512B safeguards genome integrity by directing DNA repair to key regulatory regions. This mechanism limits inflammatory signaling and the senescence-associated...

cell.com
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Designing complex organoids through developmental principles dlvr.it/TTKbL7

Designing complex organoids through developmental principles

Brassard and Wells discuss how next-generation human pluripotent stem cell-derived organoids are achieving greater cellular complexity by more faithfully reproducing developmental processes. Advances...

cell.com
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Generation of human appetite-regulating neurons and tanycytes from pluripotent stem cells dlvr.it/TTKZ06

Generation of human appetite-regulating neurons and tanycytes from pluripotent stem cells

Abay-Nørgaard, Mueller, Hänninen, et al. generate cultures of the hypothalamic arcuate nucleus from hPSCs. They show transcriptional similarity to human ARC and response to appetite-regulating cues....

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Evolving strategies for lineage tracing: Genetic markers, synthetic barcodes, and natural variants dlvr.it/TTKX8R

Evolving strategies for lineage tracing: Genetic markers, synthetic barcodes, and natural variants

This review synthesizes three pillars of lineage tracing—genetic markers, synthetic barcodes, and natural variants—and their integration with single-cell multi-omics and spatial profiling. It...

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Autologous macrophage therapy increases transplant-free survival in cirrhosis: Long-term follow-up of a phase 2 clinical trial dlvr.it/TTKTXd

Autologous macrophage therapy increases transplant-free survival in cirrhosis: Long-term follow-up...

Brennan and Kilpatrick et al. report long-term outcomes in patients with cirrhosis treated with autologous monocyte-derived macrophage therapy. Macrophage-treated patients demonstrated a significan...

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Human amygdala-like telencephalic organoids model stress circuitry in assembloid systems dlvr.it/TTKQ0C

Human amygdala-like telencephalic organoids model stress circuitry in assembloid systems

Yang and colleagues generated human amygdala-like telencephalic organoids (hATOs) and amygdala-hypothalamic (hATO-hypoTO) assembloids to model the brain’s stress circuitry. They demonstrate that...

cell.com
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Human retinal organoids functionally bridge a transected optic nerve in a rat model dlvr.it/TTKMgw

Human retinal organoids functionally bridge a transected optic nerve in a rat model

Gong and colleagues demonstrate that transplanting retinal organoids into a completely transected optic nerve enables partial restoration of visual function by forming a relay-like connection between...

cell.com
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Register before July 24, 2026, to save for the @CellPressEvents #CSAging2026 (October 4–6, 2026, Seville, Spain)! Hear keynote speaker Luigi Ferrucci @NIHAging & leading experts advancing the future of aging research. hubs.li/Q04n47qF0
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Online Now! Patient-derived organoids reveal ductal dysfunction and CFTR-modulator responses in chronic pancreatitis dlvr.it/TTHRP2 #stemcells

Patient-derived organoids reveal ductal dysfunction and CFTR-modulator responses in chronic...

Chronic pancreatitis lacks disease-modifying therapies and robust human models. Engle and colleagues establish patient-derived organoids that preserve epithelial disease programs, reveal heterogene...

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The extended abstract submission deadline for the @CellPressEvents #CSAging2026 is today. Don't miss the opportunity to present your research, connect with experts from across the field, and contribute to discussions on the future of aging research. hubs.li/Q04mgKPb0
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Cell Stem Cell reposted
Omer Yilmaz
@ohyilmaz
Jun 24
Excited to share our new @CellStemCell study from @kochinstitute @MIT: "Lineage plasticity driven by GATA6 loss fuels colorectal cancer metastasis." Led by two former lab postdocs—Saori Goto (first author) & Nori Goto, now running his own lab. kwnsfk27.r.eu-west-1.awstrac…
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Online Now! Lineage plasticity driven by GATA6 loss fuels colorectal cancer metastasis dlvr.it/TT8wr5 #stemcells

Lineage plasticity driven by GATA6 loss fuels colorectal cancer metastasis

Goto and colleagues establish a pro-metastatic colorectal cancer organoid library through the serial orthotopic transplantation of liver metastasis-derived organoids and identify GATA6 loss as a...

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We're thrilled to announce the speaker lineup for @CellPressEvents @CPSOrganoidsNAMs27, including keynote speakers @DonIngber, @MummeryLab & Mark Skylar-Scott @StanfordDeptMed View the full lineup: hubs.li/Q04lQTWp0
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Online Now! Quantitative molecular cartography of emergency myelopoiesis reveals conserved modules of hematopoietic activation dlvr.it/TT6316 #stemcells

Quantitative molecular cartography of emergency myelopoiesis reveals conserved modules of hematop...

Swann et al. conducted a comparative analysis of single-cell RNA-sequencing data from emergency myelopoiesis models, finding that different perturbations act at distinct levels of the hematopoietic...

cell.com
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Online Now! Paired pre- and post-transplant human immunoprofiling identifies an IFN-γ-JAK1 axis limiting stem-cell-derived RPE engraftment dlvr.it/TT55LK #stemcells

Paired pre- and post-transplant human immunoprofiling identifies an IFN-γ-JAK1 axis limiting...

Gao et al. identify a Th1-biased, IFN-γ-rich immune state that reprograms hESC-RPE immunogenicity through JAK1 signaling. Brief ex vivo ruxolitinib conditioning dampens HLA induction and immune...

cell.com
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