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Cell Reports @CellReports

Cell Reports is an open-access journal at Cell Press, publishing weekly. Tweets by Cell Reports editors.

Joined July 2011
  • Posts 16,576
  • Following 142
  • Followers 148,836
2,023 Photos and videos
Type I unconventional protein secretion of the SARS-CoV-2 nucleocapsid protein promotes inflammatory cytokine release dlvr.it/TTNDGN

Type I unconventional protein secretion of the SARS-CoV-2 nucleocapsid protein promotes inflammat...

Zheng et al. characterize a type I unconventional protein secretion pathway that releases phosphorylated, oligomeric SARS-CoV-2 NP into the extracellular space. This secreted NP stimulates granuloc...

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Pyruvate-formate lyase-derived formate regulates the response of Salmonella Typhimurium to meropenem and ciprofloxacin dlvr.it/TTN8Pr

Pyruvate-formate lyase-derived formate regulates the response of Salmonella Typhimurium to merope...

Mukherjee et al. demonstrate that intracellular formate generated by PflB strongly influences Salmonella sensitivity to meropenem and ciprofloxacin. Intracellular formate depletion disrupts pH...

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GRHL and PGR control WNT4 expression via 3D looping of conserved and species-specific enhancers dlvr.it/TTLYhk

GRHL and PGR control WNT4 expression via 3D looping of conserved and species-specific enhancers

Steroid hormones ensure flexible yet robust developmental gene expression. Van de Grift et al. dissect the WNT4 locus in the mouse and human mammary gland, revealing that lineage factors GRHL and PGR...

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The calcium pump ATP2B1/PMCA1 regulates CNS vascular development by facilitating Norrin- and WNT7A/B-induced Frizzled4 signaling dlvr.it/TTLTnK

The calcium pump ATP2B1/PMCA1 regulates CNS vascular development by facilitating Norrin- and...

Jo et al. identify the plasma membrane Ca2 −pump ATP2B1/PMCA1 as a regulator of endothelial Norrin/Frizzled4 and Wnt signaling in the CNS vasculature. Loss of ATP2B1 elevates intracellular Ca2 and...

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Paf1 Counteracts transcriptional arrest to maintain rDNA stability during pol I elongation dlvr.it/TTLRZN

Paf1 Counteracts transcriptional arrest to maintain rDNA stability during pol I elongation

Zhong, Yokoyama et al. propose that transcription defects in paf1 mutants promote R-loop formation and exposure of single-stranded DNA, contributing to rDNA instability and fragmentation.

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Red bone marrow hosts metabolically active anucleate adipocytes that support hematopoiesis dlvr.it/TTLKC3

Red bone marrow hosts metabolically active anucleate adipocytes that support hematopoiesis

Shin et al. show that human regulatory BMAds (rBMAds) are anucleate cells but metabolically active, displaying lipid and glucose metabolism while lacking lipolytic capacity. They secrete factors that...

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Histone lactylation-driven intratumoral IGFBP2 NK cells promote tumor immune evasion dlvr.it/TTLD7D

Histone lactylation-driven intratumoral IGFBP2 NK cells promote tumor immune evasion

Wang et al. identify an immunoregulatory subset of IGFBP2 NK cells in liver cancer, driven by hypoxia-induced histone lactylation. NK-secreted IGFBP2 helps tumors evade immunity by suppressing...

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Sleep lowers waking theta frequency in the rat hippocampus dlvr.it/TTL9Bs

Sleep lowers waking theta frequency in the rat hippocampus

Here, Kaya et al. reveal that hippocampal theta frequency is dynamically tuned by recent sleep, a modulation that is blunted with aging but can be restored pharmacologically, highlighting theta...

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Recurrent ZC3H18 mutations stabilize oncogenic endogenous retroviral RNA dlvr.it/TTL5fQ

Recurrent ZC3H18 mutations stabilize oncogenic endogenous retroviral RNA

Truncating mutations in the nuclear RNA surveillance factor ZC3H18 (Z18) recur across cancers and drive melanoma by stabilizing endogenous retroviral (ERV) RNA. Using zebrafish models, cancer cell...

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De novo pyrimidine synthesis controls germinal center B cell and plasma cell fates and systemic autoimmunity dlvr.it/TTKgDj

De novo pyrimidine synthesis controls germinal center B cell and plasma cell fates and systemic...

Weber et al. unravel a role of de novo pyrimidine synthesis in systemic autoimmunity. Conditional deletion of UMPS, a key enzyme in pyrimidine metabolism, shows a B cell-intrinsic requirement of this...

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Cd99l2 regulates excitatory synapse development and restrains immediate-early gene activation dlvr.it/TTKZhp

Cd99l2 regulates excitatory synapse development and restrains immediate-early gene activation

(Cell Reports 44, 115155; January 28, 2025)

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Pancreatic α-cells integrate immune and neuronal stimuli for insulin secretion dlvr.it/TTKWr7

Pancreatic α-cells integrate immune and neuronal stimuli for insulin secretion

Trimigliozzi et al. show that α-cells integrate neuronal and immune signals to release glucagon, which acts on β-cell glucagon and GLP-1 receptors to drive insulin secretion at fasting glucose...

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SPINDOC functions as a mitotic molecular counter to coordinate spatiotemporal CENP-A assembly dlvr.it/TTKNbD

SPINDOC functions as a mitotic molecular counter to coordinate spatiotemporal CENP-A assembly

Zhang et al. demonstrate that during mitosis, SPINDOC safeguards a specific pool of CENP-ApS68 from degradation while presenting CENP-A to HJURP for its spatiotemporal deposition. SPINDOC coordinates...

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Divergent toxicity mechanisms of amyloid-beta aggregates arising from a single aggregation reaction dlvr.it/TTKGsH

Divergent toxicity mechanisms of amyloid-beta aggregates arising from a single aggregation reaction

Metodieva et al. use organotypic hippocampal slices and advanced imaging tools to show that distinct amyloid-β species trigger different cellular responses. Early species disrupt neuronal calcium and...

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Activation-induced SLC7A1 expression enhances T cell sensitivity to cGAMP-mediated STING signaling dlvr.it/TTKCT0

Activation-induced SLC7A1 expression enhances T cell sensitivity to cGAMP-mediated STING signaling

Sudaryo et al. identify the arginine transporter SLC7A1 as a cGAMP transporter in T cells. Activated T cells upregulate SLC7A1 for metabolism, inadvertently importing cGAMP and STING agonists that...

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Lipid droplet-mitochondria tethering releases MAVS inhibition to potentiate antiviral immunity dlvr.it/TTK7WC

Lipid droplet-mitochondria tethering releases MAVS inhibition to potentiate antiviral immunity

Peng et al. show that viral infection induces the formation of lipid droplets (LDs), which physically interact with mitochondria via LD-resident PLIN3 and mitochondrial MFN2. This interaction...

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Stiffness-induced impairment of GLUT4 trafficking in adult cardiomyocytes dlvr.it/TTJhyb

Stiffness-induced impairment of GLUT4 trafficking in adult cardiomyocytes

Pathological stiffness disrupts glucose uptake in cardiomyocytes by altering microtubule-dependent GLUT4 trafficking. This study links mechanical stress to metabolic dysfunction and contractile...

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Addition of blood-stage antibody enhances anti-sporozoite antibody protection in a humanized mouse model of Plasmodium falciparum infection dlvr.it/TTJcQh

Addition of blood-stage antibody enhances anti-sporozoite antibody protection in a humanized mouse...

Kirtley et al. test the benefits of a multi-stage approach against infection with Plasmodium—the causative agent of malaria. Using a humanized mouse model, they show that the addition of a blood-st...

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Impaired behavioral inhibition in Fmr1 KO mice is linked to disrupted visual cortex theta oscillations dlvr.it/TTJYdc

Impaired behavioral inhibition in Fmr1 KO mice is linked to disrupted visual cortex theta oscilla...

Zimmerman et al. show loss of behavioral inhibition correlated with attenuated theta activity in the primary visual cortex, hippocampus, and deficient top-down control from the prefrontal cortex in...

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Dual blockade of PD-1 and NKG2A prevents NK cell senescence and reprograms the immunosuppressive microenvironment in pancreatic cancer dlvr.it/TTJQ45

Dual blockade of PD-1 and NKG2A prevents NK cell senescence and reprograms the immunosuppressive...

Zhang et al. show that PD-1 blockade induces IFNγ-dependent H2-T23 upregulation in pancreatic tumor cells, promoting NK cell senescence through H2-T23/NKG2A-p38-STAT1/3 signaling. Dual PD-1 and NKG2A...

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